Looking up villainous organizations on the web, I knew I was on to something when a Wikipedia article about a TV show terrorist network carried this disclaimer “The neutrality of this article is disputed.”
S.P.E.C.T.R.E. -SPecial Executive for Counter-intelligence, Terrorism, Revenge and Extortion (James Bond, after SMERSH and behind FIRCO)
T.H.R.U.S.H. -Technological Hierarchy for the Removal of Undesirables and the Subjugation of Humanity, formally WASP (Man from UNCLE)
C.H.U.M.P. -Criminal Headquarters for Underworld Master Plan (Lancelot Link)
S.C.U.M. -Saboteurs and Criminals United in Mayhem (James Bond animated series)
T.A.R.O.T. -Technological Accession, Revenge, and Organized Terrorism (James Bond game)
M.A.D. -Mean And Dirty (Inspector Gadget)
F.O.W.L. -Fiendish Organization of World Larceny (Darkwing Duck)
E.V.I.L. -Every Villain Is Lemons (Spongebob)
S.P.O.R.E. -Sinister People Organized Really Efficiently (Dr. Brain)
BIG O (Matt Helm)
KAOS (Get Smart)
GALAXY (Our Man Flynt)
COBRA (GI Joe)
AL QAEDA [IN IRAK] -Central Intelligence Agency or other members of the U.S. I.C. – DNI, USDI, NSA, NRO, NGA, DIA, INR, AFI, AI, NI, MCI, DEA, DHS, FBI.